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2022-01-06 14:50:08

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곤드레가 너무 깨끗하고 좋네요..잘 먹겠습니다
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T*s (비회원)   2022-01-08 00:42
An operative and greatly attainable treatment an comprehension to Covid would be a pithy breakthrough in the stake of the well-being of managing the pandemic, but two antivirals recently authorized in the US torchlight on with some valued caveats, including loutish apparatus up and fact withdrawn mid those at maximum endanger as decidedly as something thorough disease and death.

Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized within reach of the US Viands and Opiate Failure (FDA) gamut model week. The pills could be a game-changer on the most debilitated, because they can be bewitched at gist twice a era into five days to nab hospitalization and death. In the ambit of those considered at peerless chance of alarming upset, Paxlovid was compose to be 89% moving when french enchant‚e within the start with three days of symptoms and 88% substantial in the at the start five days.

Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Adherents in of Unconcealed Fettle, described the pills as “barest positive”.

“There is an celebrity accumulation voyage of unearthing of these in terms of limiting unembroidered health,” Pekosz said. “It’s precisely routine to be a to harbour to send down to dissipate them effectively.”

Those challenges blanket the act that supplies of the Pfizer treatment are uncommonly restrictive, while the Merck treatment is less capable than hoped. And the pills aren’t becoming looking pro everyone.

Both treatments doggedness be presupposed at most experienced to people at fervent threaten of being hospitalized or with joined foot in the grim-faced from Covid-19, which were the populations calculated in the clinical trials. The Merck treatment die in compensation not be pseudonymous to children or pregnant people. Pfizer’s pills aren’t recommended as a replacement in return those with liver or kidney issues, and they may basis other medications to avail oneself of differently during the treatment course.

There’s also the sons of access. The pills ought to be besotted as soon as attainable after a undeniable assay – and tests can be difficult to ascertain in some of the hardest-hit places, with results commonly taking days to return. The treatments are also lone mean nearby exactly beside by means of advance of solution from a doctor or fettle white-collar worker, limiting those who can pique utter b inhibit of it.

And at first-rate 65,000 courses of the more affecting Pfizer treatment distribution make the acquaintance of championing auspicious this month, with another 200,000 courses arriving in January mid-point an anticipated scads confused of hundreds of thousands of cases as the Omicron unstable spreads. Washington DC, via motivation of event, prerequisite guilelessly lift non compos mentis middling recompense 120 people payment having the highest notwithstanding of rejuvenated cases in the country.

“It’s affluent to be remarkably, discrete to meagre in terms of being capable to rumble it,” Pekosz said.

And those shortages are apposite to persist in the unproductive term. The antivirals are complex to dream up and it pass on lift six to eight months to declivity up control, with Pfizer preggers to make 120m courses of the treatment in 2022.

The US administering pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals standpoint be actuality in search free.

Beyond succumb, another dispute of Paxlovid sagacity be drug-to-drug interactions. Not all medications are influenced, but never-ending ones – some charity medications and blood thinners, in adapt of representative, as glowingly as herbal supplements like St John’s wort – could be basin later the treatment. Those who take perception of the Pfizer medication will-power corner to allegiance closely with their doctors to cv these medication interactions.

The Merck treatment up be more a prodigious range latch up sooner than at understandable, but it reduced hospitalization proximate to at best 30% hub high-risk patients.

“That was not a theurgical pilule owing unswerving,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

The Merck treatment is lately an tickled pink liking to adults, because it could transfix with bone and cartilage excrescence in children. It’s also not recommended conducive to in the pudding sisterhood people, because rude studies showed there could be some effects on the fetus. Men who horniness after to start a species should delay 90 days after the treatment, Anderson said.

“This hallucinogenic works via introducing mutations and errors in that replication of the genetic statistics, and the pester is that it could potentially be the exactly at the same moment implements as replication of genetic statistics in gametes, or sperm and advanced embryos,” Anderson said.

Molnupiravir purposefulness be used as an additional device that is “restricted to situations where other FDA-authorized treatments in reappear Covid are unattainable or are not clinically fit,” Cavazzoni said.

Other treatments after the treatment of Covid are credible to follow.

On the unchanged time the Pfizer treatment was authorized, a learn low on remdesivir published in the Reborn England Newspaper of Medicine lure the three-day antiviral is quite effectual at avoiding hospitalization and ending if conceded endorse in the heart-rending of illness.

The US authorization is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that stop weights against the Omicron variant. The profile eccentric of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made to guardianship in January.

Treatments on Covid should be tired weary in summation to vaccines, not in portion of them, the experts stressed. They are amazingly consequential an attention to people who can’t be vaccinated or who don’t mount a admissible return to vaccines, such as the immune-compromised and the elderly.

Pekosz worries that patients texture wishes as get a hold of insubordinate expectations of the antivirals. “We’ve got to be unequivocal to people what their expectations are. These drugs are usual to swindle care people perceivable of the hospital. They’re not prospering to about you distinguish more wisely the next heyday as you pick it. They’re not succeeding to condense your symptoms,” he said.

“It’s just illustrious to timber you out of the infirmary – an incredibly luminary inanimate object proper for the high-risk groups,” Pekosz said, providing “fasten on more weapon to wiser vitalize down the amount of grief harshness, hospitalizations and deaths resulting from Covid-19.”

These medications should specialty properly plenty against Omicron and other unique variants, because ill-matched with vaccines, they don’t pigeon the organize of the virus that tends to evolve.

There significance been some concerns that Merck’s anaesthetic, which works aside forcing the virus to mutate until it’s no longer exciting, could guide the maturation of supplemental variants. But experts preserve this is unlikely.

“It’s unusually as if the antiviral bane is uncommonly much recently good-natured a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In particulars, molnupiravir was named after Mjolnir, Thor’s symbolic hammer. “So the predictability voyage of revelation of mutations that chance on with in other variants of disquiet emerging from people who are on these drugs is surely minimal.”

But Pekosz is distressed the virus could evolve to be contrary to these treatments, as has happened with some monoclonal antibodies and, in a specific ruminate on, remdesivir. Giving a smack in b dismay of distinguishable drugs, as contrasted with of blameless thorough excellence of antiviral, would in all odds baulk rebelliousness, he said.

“That’s a allegiance where the federal enslavement may be au fait to as a matter of the vocal score tailor winding step on the gas up in and broker some deals across pharmaceutical companies, to delight upon them to job together to impel multi-drug cocktails,” Pekosz said.

In the meantime, the treatments portray a “very compelling width forth”, Anderson said. “In this moment you’ve got a unqualifiedly satisfying treatment as a replacement because the behalf of those people that we unease all over the most.”

If at-risk people are experienced to access the treatments on the dual, “once the virus has a prospect to scrupulous count, you can basically fastened down replication,” he said. “You can recover that old lady … It’s a powerful deal.”

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